Endocrine Abstracts

Context: It is well established that clinical features of acromegaly concern the teeth and the jaw, but less is known about the degree of oral and maxillofacial pathologies and its impact of the disease duration.Patients: Twenty-eight acromegalics (13 females, 15 males) with a mean age 49±11 (mean±S.D.) years (range 31–70) were included in the study. Thirty-two percent had active disease, 39% were well-controlled under the s...

Objective: The ITT is the gold-standard for assessment of GH and ACTH reserve but has certain contraindications. GH and cortisol responses of <3 ng/ml and <500 nmol/l, respectively, have been defined as evidence of severe deficiency. The GST like the ITT stimulates both the ACTH and GH secretion and is suggested to be a good alternative in terms of efficiacy. However, there are limited prospective data with modern assays on sensitivity and specificity for the GST in co...

Objective: Gastroenteropancreatic neuroendocrine neoplasm (GEP-NENs) are rare and heterogeneous in their tumor biology. Therapeutic options to prevent growth and dissemination are still not satisfactory. As shown previously, survivin and aurora kinases (members of the mitotic chromosomal passenger complex) play a role in cell cycle progression; FOXM1 is a transcription factor that regulates G2/M progression and is associated with grading and metastasis in GEP-NENs. Aurora kina...

Recent data suggest that hypopituitarism is a common complication of TBI. Prevalence differs between 10–40% and is based on different diagnostic tests and criteria. Hence, under field conditions TBI-mediated hypopituitarism may be less frequent than previously thought. We determined the prevalence of anterior pituitary dysfunction in a multi-centre screening program across five German endocrine centres in patients rehabilitating from TBI (GCS<13).<p class="abstext...

The influence of first-line transsphenoidal surgery (TSS) or first-line somatostatine analogue (SSA) treatment on coronary risk factors in patients with acromegaly has rarely been examined. Aim of this study was to evaluate risk factors for coronary heart disease in 3 different patient groups with treatment naïve, active (ACT), first-line medically controlled (MED) and first-line surgically treated (SUR) acromegaly and to calculate the Framingham Risk Score (FS).<p cl...